"The majority of cases are sporadic, however, 20-40% may relate to an autosomal gene. Typically FTLDs occur in younger patients than Alzheimer disease, usually with onset between 40-60 years of age (60%) and 10% being diagnosed"
"The majority of cases are sporadic, however, 20-40% may relate to an autosomal gene. Typically FTLDs occur in younger patients than Alzheimer disease, usually with onset between 40-60 years of age (60%) and 10% being diagnosed"
"FTLD-TDP: transactive response DNA binding protein 43 (TDP-43)"
"FTLD-TDP: transactive response DNA binding protein 43 (TDP-43)"
"FTLD-FUS: fused in sarcoma protein (rare)"
"FTLD-TDP: GRN (granulin), C9ofr72, VCP, and TARBP (TDP-43) genes"
"FTLD-FUS: bilateral caudate nuclei"
"FTLD-TDP due to GRN mutation: right frontal, lateral temporal and parietal lobes, often markedly asymmetric when comparing hemispheres 9"
"FTLD-TDP due to C9orf72 mutation: bilateral hemispheres (generalised)"
"FTLD-TDP: GRN (granulin), C9ofr72, VCP, and TARBP (TDP-43) genes"
Expected headings
"Terms to use with care"
"The conditions grouped under this term vary from publication to publication, depending on whether clinical, pathological or genetic factors are used in the classification and when they were published."
"Frontotemporal dementia was first described by Arnold Pick (1851-1924), Czech psychiatrist, neurologist and neuropathologist, in 1892 11,12."