"Goodpasture’s syndrome accounts for 1-2% of cases of rapidly progressive glomerulonephritis. It can occur at any age but most commonly affects men aged 20 - 30 with an M:F of 3:1. Smoking commonly predates pulmonary haemorrhage. Other risk factors may include hydrocarbon exposure, infections such as influenza and HLA type."
"Goodpasture syndrome, also referred as antiglomerular basement membrane (anti-GBM) antibody disease, is an autoimmune disease characterised by damage to the alveolar and renal glomerular basement membranes by a cytotoxic antibody. It is a type of pulmonary-renal syndrome."
"Patients may present with cough, dyspnoea, haemoptysis, hypoxaemia, anaemia, fatigue, chest pain, uraemia or haematuria. Hypertension is rare."
"Patients may present with cough, dyspnoea, haemoptysis, hypoxaemia, anaemia, fatigue, chest pain, uraemia or haematuria. Hypertension is rare."
"Goodpasture syndrome is a type II hypersensitivity reaction with antibodies primarily directed against type IV collagen of the renal glomerular basement membrane. There is further cross-reactivity with the alveolar basement membrane resulting in pulmonary injury. This is typically characterised by rapidly progressive glomerulonephritis (RPGN) and necrotising haemorrhagic interstitial pneumonitis respectively."