"Dual sequences MR imaging (gradient in and out phase) demonstrates decreased signal intensity in the iron-loaded tissues on the in-phase images compared with the out-phase images (opposite of what you would see with microscopic fat deposit as in hepatic steatosis). This occurs because the echo time of the in-phase sequence is usually higher than that of the out-phase sequence; therefore, the in-phase pulse sequence is more sensitive to iron deposits because of the increased T2* effect 2."