"metabolic dysfunction–associated steatohepatitis (MASH)"
"Some consider the terms "non-alcoholic" and "fatty" derogatory, and steatotic liver disease is now preferred 12, although the former terms remain in common use. Additionally, the use of the term "fatty infiltration" is incorrect because the abnormal lipid accumulation is intracellular, not extracellular."
"Steatotic liver disease includes several separate entities 12:"
"The degree of diffuse hepatic steatosis can be graded using several scoring systems, including the commonly used Saverymuttu grading system (see diffuse hepatic steatosis grading), the Hamaguchi score, US-FLI score, and hepatorenal sonographic index 2."
"monogenic liver diseases (e.g. Wilson disease)"
"Liver biopsy is the gold standard for diagnosis; the histological definition requires a minimum of 5% macrovesicular steatosis 5. Liver tests may be normal or liver enzymes may be elevated if the liver is inflamed. Imaging can also be used to assess fat content, see below."
"Clinical features include fatigue, right upper quadrant pain, and hepatomegaly; most individuals are asymptomatic."
"Histology shows macrovesicular lipid accumulation within the affected hepatocytes, with or without inflammation 6."