"T1: hypointense, often subtly so"
"T2/FLAIR: hyperintense"
"DWI: may have high signal (true diffusion restriction), particularly at the peripheries of T2/FLAIR abnormalities"
"T1 C+ (Gd): may have enhancement, particularly punctate or linear enhancement in a radial perivascular distribution"
"T2: hyperintense"
"T1 C+ (Gd): there may be enhancement"
"In one case report, a similar pathology been postulated to occur in the spinal cord, described as HIV-associated CD8+ transverse myelitis, or CD8+ myelitis 7."
"In one case report, a similar pathology been postulated to occur in the spinal cord, described as HIV-associated CD8+ transverse myelitis, or CD8+ myelitis 7."
"Black ethnicity"
"In analysis of the cerebrospinal fluid (CSF), most patients demonstrate 'viral escape', with higher levels of HIV RNA present in the CSF compared to the serum 1-3. Additionally, there is also a lymphocytic pleocytosis 1."
"autoimmune GFAP astrocytopathy 8"
"MRI changes often ependymal/subependymal and enhancement is usually more homogenous"
Expected headings
"Macrovascular appearance"
"There is an acute or subacute presentation of encephalopathy, including 1-3:"
"There is perivascular and intraparenchymal infiltration by CD8+ T cells 1,3,4. This is most florid in the white matter 1,3,4. The presence of HIV is generally not demonstrable with immunohistochemistry 1,3,4."
"MRI brain is always abnormal 1. Characteristic findings include bilateral, diffuse, symmetric and confluent signal changes throughout the supra- and infratentorial white matter, with or without accompanying and extending similar changes throughout the deep grey matter 1-6,8."
"MRI brain is always abnormal 1. Characteristic findings include bilateral, diffuse, symmetric and confluent signal changes throughout the supra- and infratentorial white matter, with or without accompanying and extending similar changes throughout the deep grey matter 1-6,8."