"T2/FLAIR: high signal"
"DWI/ADC: restricted diffusion"
"SWI: blooming artefact indicating haemorrhage is usually absent"
"SWI: blooming artefact indicating haemorrhage is usually absent"
"Human herpesvirus 6 (HHV-6) encephalitis, also known as human herpesvirus 6 (HHV-6) encephalopathy, is a rare CNS manifestation caused by human herpesvirus 6 infection."
"Human herpesvirus 6 (HHV-6) encephalitis, also known as human herpesvirus 6 (HHV-6) encephalopathy, is a rare CNS manifestation caused by human herpesvirus 6 infection."
"HHV-6 infections are ubiquitous globally, with up to 95% seropositivity in adults 7. HHV-6 encephalitis is rare and can occur during primary infection or reactivation, with the latter being more common 10."
"HHV-6 infections are ubiquitous globally, with up to 95% seropositivity in adults 7. HHV-6 encephalitis is rare and can occur during primary infection or reactivation, with the latter being more common 10."
"HHV-6 encephalitis is typically seen in immunocompromised individuals (e.g. haematopoietic stem cell transplant, solid organ transplant or HIV-positive patients), who develop a characteristic limbic encephalitis syndrome with MRI abnormalities confined to the mesial temporal lobes 1,7."
"Other clinical presentations that may accompany HHV-6 reactivation in immunocompromised patients include rash, pneumonitis, gastrointestinal disease, bone marrow suppression and concomitant CMV reactivation 11."
"HHV-6 consists of two closely related double-stranded herpesviruses: HHV-6A and HHV-6B. Both have been implicated in encephalitis, with HHV-6B being more prevalent and better characterised 7,8."
"HHV-6 consists of two closely related double-stranded herpesviruses: HHV-6A and HHV-6B. Both have been implicated in encephalitis, with HHV-6B being more prevalent and better characterised 7,8."
"HHV-6 consists of two closely related double-stranded herpesviruses: HHV-6A and HHV-6B. Both have been implicated in encephalitis, with HHV-6B being more prevalent and better characterised 7,8."
"HHV-6 consists of two closely related double-stranded herpesviruses: HHV-6A and HHV-6B. Both have been implicated in encephalitis, with HHV-6B being more prevalent and better characterised 7,8."
"HHV-6B is also well established to be the cause of roseola infantum (sixth disease), a common and self-limiting infection in children 9."
"HHV-6 was first isolated in 1986 during a study of patients with lymphoproliferative disorders and AIDS in the United States 12."
"more likely to have an abnormal CT brain than HHV-6 encephalitis"
"more likely to involve extratemporal regions than HHV-6 encephalitis"
"more likely to have parenchymal swelling than HHV-6 encephalitis"
"more likely to have haemorrhage than HHV-6 encephalitis"
"HHV-6 false positivity on multiplex polymerase chain reaction (PCR) panels of cerebrospinal fluid (CSF) is well-described, and thus, interpretation of a positive result should be made in the context of the patient demographics, clinical presentation, radiographic features, and quantitative viral load studies 5."
"HHV-6 encephalitis is typically seen in immunocompromised individuals (e.g. haematopoietic stem cell transplant, solid organ transplant or HIV-positive patients), who develop a characteristic limbic encephalitis syndrome with MRI abnormalities confined to the mesial temporal lobes 1,7."
"MR spectroscopy"
"reduced N-acetyl aspartate levels"
Expected headings
"MR spectroscopy"
"The clinical presentation is somewhat non-specific, resembling a limbic encephalitis 3. Common clinical features include confusion and altered consciousness, headache, fever, nausea and vomiting, seizures, and focal neurological deficits 3."