"There is almost no data on the safety of hyoscine or related agents during pregnancy, most published data is from its use at the time of labour. No research has examined whether there is an increased chance of miscarriage, stillbirth, premature delivery or intrauterine growth restriction. Official advice in the UK is that "the use of hyoscine during pregnancy may be justified where there is a clear clinical indication." 7,8."
"Hyoscine-N-butylbromide, also known as scopolamine, and more commonly known by its brand name, Buscopan, is an antimuscarinic agent, widely used in radiology as an antispasmodic agent. It is employed to freeze bowel motion as part of many fluoroscopic, CT and MRI studies (its main use for many years was for barium GI studies). It is widely used in Europe but unlicensed in the USA; hence an alternative agent, glucagon is often employed."
"Hyoscine-N-butylbromide, also known as scopolamine, and more commonly known by its brand name, Buscopan, is an antimuscarinic agent, widely used in radiology as an antispasmodic agent. It is employed to freeze bowel motion as part of many fluoroscopic, CT and MRI studies (its main use for many years was for barium GI studies). It is widely used in Europe but unlicensed in the USA; hence an alternative agent, glucagon is often employed."
"From 1963-2006 in the UK there were only 12 reported cases of cardiac side-effects, and only one fatality 1. Even allowing for likely under-reporting of complications, this is still an impressive lack of serious adverse effects, when one considers that literally millions of safe doses were administered during this 43-year period."
"Rarely, hyoscine-N-butylbromide may trigger acute angle-closure glaucoma (AACG), one of the causes of an acute red eye. This is an ophthalmological emergency, as untreated it is sight-threatening, however, as long as patients attend an ED and are treated promptly their vision will not be at risk. Unfortunately, patients with this condition do not know they are at risk in advance of an attack and it has a completely different pathogenesis to the open-angle form. Therefore, it is of limited value asking about a history of glaucoma prior to giving the drug but rather counselling the patient about the signs and symptoms of acute angle-closure glaucoma and to attend for emergency care 9,10."
"There is almost no data on the safety of hyoscine or related agents during pregnancy, most published data is from its use at the time of labour. No research has examined whether there is an increased chance of miscarriage, stillbirth, premature delivery or intrauterine growth restriction. Official advice in the UK is that "the use of hyoscine during pregnancy may be justified where there is a clear clinical indication." 7,8."
"Hyoscine-N-butylbromide is a chemical derivative of hyoscine, which is chemically an alkaloid and was originally plant-derived, from the Solanaceae (nightshade) family. Atropine, another well-known antimuscarinic agent was also originally derived from a plant from the same family."
"Scopolamine derives its name from one of the plants in the nightshade family, Scopolia carniolica. This itself was named after its presumptive discoverer, J A Scopoli 5. Hyoscine also takes its name from a member of the nightshade family, Hyoscyamus niger 6. Buscopan was first brought to the market in 1951 4."
Expected headings
"Pharmacology"
"Biochemistry"
"Administration"
"Glaucoma"
"Allergy"
"Pregnancy"
"Hyoscine-N-butylbromide, also known as scopolamine, and more commonly known by its brand name, Buscopan, is an antimuscarinic agent, widely used in radiology as an antispasmodic agent. It is employed to freeze bowel motion as part of many fluoroscopic, CT and MRI studies (its main use for many years was for barium GI studies). It is widely used in Europe but unlicensed in the USA; hence an alternative agent, glucagon is often employed."
"In adults, the standard dosage is 20 mg usually administered IV or IM. It can also be given orally, rectally or subcutaneously, but these routes are generally avoided in imaging ref."
"Hyoscine-N-butylbromide, also known as scopolamine, and more commonly known by its brand name, Buscopan, is an antimuscarinic agent, widely used in radiology as an antispasmodic agent. It is employed to freeze bowel motion as part of many fluoroscopic, CT and MRI studies (its main use for many years was for barium GI studies). It is widely used in Europe but unlicensed in the USA; hence an alternative agent, glucagon is often employed."
"A history of chronic open-angle glaucoma (COAG) is not a contraindication; despite this many departments continue to withhold its use in patients with a history of ‘glaucoma’. The misunderstanding derives from hyoscine-N-butylbromide’s propensity to rarely precipitate acute angle-closure glaucoma (AACG), an entirely different form of the disease (see complications below)."
"prostatism: Buscopan can inhibit the detrusor muscle, conceivably triggering acute retention; however, this does not seem to be an issue, probably due to its short duration of action"
"A true immune-mediated allergy is very rare, with only a few reported cases 1. Angioneurotic oedema has rarely been reported 2; anaphylaxis is equally rare 3."
"Buscopan may cause an elevation in the heart rate - an antimuscarinic effect - and this may exacerbate symptoms in those with unstable cardiac disease: namely acute coronary syndrome, recurrent cardiac pain at rest, uncontrolled left ventricular failure, and recent ventricular arrhythmias. There is no concern in other cardiac diseases, e.g. well-controlled ischaemic heart disease, atrial fibrillation."
"There is almost no data on the safety of hyoscine or related agents during pregnancy, most published data is from its use at the time of labour. No research has examined whether there is an increased chance of miscarriage, stillbirth, premature delivery or intrauterine growth restriction. Official advice in the UK is that "the use of hyoscine during pregnancy may be justified where there is a clear clinical indication." 7,8."
"History and etymology"