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Lint: hypophosphatasia

hypophosphatasia
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"The underlying genetic abnormality is almost exclusively due to a mutation in the ALPL gene that encodes for tissue non-specific alkaline phosphatase (TNSAP) enzyme. This results in defective bone mineralisation and extracellular accumulation of TNSAP substrates. With over 300 different specific mutations recognised, the severity of the resultant clinical disorder depends on the degree to which TNSAP activity is impaired. The severer the impairment, the earlier the presentation."

Line 8:86 · Italics should be used only in exceptional circumstances: '<em>ALPL </em>'
List Caps
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"Looser zones 6"

Line 35:4 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Headings Valid
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Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Subtypes"

Line 9:1 · "Subtypes" is not a recognised heading for this article type.

"Skeletal manifestations"

Line 26:1 · "Skeletal manifestations" is not a recognised heading for this article type.
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