"≥50% decrease in the sum of products of two longest perpendicular diameters (SPD) of soft tissue plasmacytoma(s) if present at baseline"
"≥50% decrease in the sum of products of two longest perpendicular diameters (SPD) of soft tissue plasmacytoma(s) if present at baseline"
"SUVmax ≥2.5 within osteolytic area >1 cm"
"SUVmax ≥1.5 within osteolytic area ≤1 cm"
"imaging plus minimal residual disease (MRD)-negative refers to flow or sequencing MRD-negative in addition to disappearance of all areas of increased FDG uptake found at prior PET to an SUVmax below that of surrounding normal tissue or below that of mediastinal blood pool (Deauville 1 or 2) 2"
"progressive disease is defined by any of the following:"
"stable disease is a category of exclusion, i.e., the patient does not meet criteria for progressive disease, minimal response, partial response, very good partial response, or complete response"
"minimal response requires all of the following:"
"partial response requires all of the following:"
"≥50% decrease in serum M-protein"
"≥50% decrease in the difference between involved and uninvolved serum free light chain (FLC) levels if serum and urine M-protein unmeasurable"
"very good partial response requires any of the following:"
"serum and urine M-protein detected by immunofixation but not electrophoresis"
"≥90% decrease in the difference between involved and uninvolved serum free light chain (FLC) levels if serum and urine M-protein unmeasurable"
"complete response requires all of the following:"
"disappearance of any soft tissue plasmacytomas"
"stringent complete response requires complete response as above plus the following:"
"normal free light chain (FLC) ratio (0.26-1.65)"
"flow or sequencing minimal residual disease (MRD)-negative requires absence of phenotypically abnormal clonal plasma cells from bone marrow aspirates using either a validated next-generation flow method (e.g. EuroFlow) or next-generation DNA sequencing method (e.g. LymphoSIGHT) that can detect 1 in 10 thousand nucleated cells or better"
"imaging plus minimal residual disease (MRD)-negative refers to flow or sequencing MRD-negative in addition to disappearance of all areas of increased FDG uptake found at prior PET to an SUVmax below that of surrounding normal tissue or below that of mediastinal blood pool (Deauville 1 or 2) 2"
"sustained minimal residual disease (MRD)-negative refers to imaging plus MRD-negative confirmed at least one year apart"
"clinical relapse requires any of the following manifestations of myeloma (CRAB features):"
"definite (≥50% and ≥1 cm) increase in the size (sum of products of two longest perpendicular diameters (SPD)) of measurable existing soft tissue plasmacytomas or bone lesions"
"definite (≥50% and ≥1 cm) increase in the size (sum of products of two longest perpendicular diameters (SPD)) of measurable existing soft tissue plasmacytomas or bone lesions"
"relapse from complete response requires reappearance/development of any of the following:"
"serum or urine M-protein by immunofixation or electrophoresis"
"relapse from minimal residual disease (MRD)-negative occurs with loss of MRD-negative status (clonal plasma cells on sequencing or flow of bone marrow, or positive lesions on FDG PET) or any of the above signs of relapse from complete response"
Expected headings
"Baseline disease"
"Standard response criteria"
"Minimal residual disease criteria"
"Relapse criteria"
"stable disease is a category of exclusion, i.e., the patient does not meet criteria for progressive disease, minimal response, partial response, very good partial response, or complete response"