"beta minus emission – cytotoxic effects"
"Azedra was FDA-approved in 2018 for the treatment of patients 12 years and older with unresectable metastatic phaeochromocytomas and paragangliomas. It is manufactured by Progenics Pharmaceuticals, Inc., a Lantheus company, in the Unites States. In August 2023, Lantheus disclosed in regulatory filings that they will ultimately stop production of Azedra, continuing into the first quarter of 2024 to provide doses to patients 6,7."
Expected headings
"Characteristics"
"Use"
"Potential side effects"
"Iodine-131 iobenguane, trade name Azedra, sometimes referred to as I-131 MIBG, is a theranostic (i.e. both therapeutic and diagnostic) agent used for the treatment of unresectable phaeochromocytomas, paragangliomas, neuroendocrine tumours, and neuroblastomas. It is produced using the high-specificity Ultratrace synthesis method to yield a high proportion of MIBG bound to the radiopharmaceutical Iodine-131, enabling specific targeting of the noradrenaline transporter."