"Unlike sporadic Creutzfeldt–Jakob disease, cerebellar ataxia and movement disorders are the predominant clinical features of kuru, rather than dementia 12. Kuru is thought to present in stages, following a mean incubation period of 3-6 years 12:"
"Pathology "
"Kuru is transmitted orally via cannibalism. The scrapie isoform of prion protein (PrPSC) is the infectious culprit agent that causes Kuru. The PrPSC unfolds, refolds, and replicates its structures, propagating smaller peptide sequences into specific peptide targets 13."
"Kuru is transmitted orally via cannibalism. The scrapie isoform of prion protein (PrPSC) is the infectious culprit agent that causes Kuru. The PrPSC unfolds, refolds, and replicates its structures, propagating smaller peptide sequences into specific peptide targets 13."
Expected headings
"Pathology "
"Since 1996 only 14 new cases have been recorded, and the last recorded death from kuru was in 2009; moreover there had been only two other deaths from it in the period 2002-2006 10."
"The disease was first described by Vincent Zigas (1920-1983), a Lithuanian physician working in Papua New Guinea, and Daniel Carleton Gajdusek (1923-2008), an American virologist working at the Walter and Eliza Hall Institute, Melbourne, Australia, in 1957 4-6."