"Classification "
"type 1 is idiopathic and is related to the marked breast overgrowth in females with BMI >30 (type 1a) or BMI"
"type 1 is idiopathic and is related to the marked breast overgrowth in females with BMI >30 (type 1a) or BMI"
Expected headings
"Classification "
"Associations"
"Complications"
"It has been defined as excessive breast tissue greater than 1.5 kg (range=0.8-2.0 kg) or at least 3% of the body weight; however, there is still no global agreement about its definition 6-8."
"Its exact aetiology is unknown; however, it is believed to be due to an abnormal response to pregnancy-related hormonal stimulation. It can occur with peripubertal breast hypertrophy, juvenile gigantomastia, obesity-related breast hypertrophy or as a complication secondary to pregnancy-related gland hypertrophy ref."
"Medical treatment is with bromocriptine administration; however surgical intervention may be required if the disorder continues to progress. The usual surgical management involves reduction mammoplasty. The resected specimen is sent for histological evaluation to exclude malignancy ref."
"Gigantomastia has been described in conjunction with hypercalcaemia, hyperprolactinaemia, deranged liver function tests, and certain autoimmune diseases like Hashimoto thyroiditis, rheumatoid arthritis, myasthenia gravis, systemic lupus erythematosus, and psoriasis 6,7,9,10."
"Significant enlargement of the breasts may cause tissue necrosis, ulceration, infection and haemorrhage, which may be life-threatening ref. Some authors believe macromastia to be associated with an increased risk of malignancy ref."