"SHH-activated TP53-wildtype medulloblastomas are twice as common as those with TP53 mutations and account for approximately 20% of all medulloblastomas. They have an M: F ratio of 1:1. They are most frequently encountered in adults (>16 years) and infants ("
"MRS: prominent choline and lipid concentrations, low creatine levels and the absence of the taurine peak10"
"MRS: prominent choline and lipid concentrations, low creatine levels and the absence of the taurine peak10"
"The name Sonic was given by Bob Riddle, a postdoctoral fellow in Cliff Tabin's lab, after seeing the character in his daughter's comic book promoting or inspired by Sega's Sonic the Hedgehog video game released in 19918,9."
"SHH-activated TP53-wildtype medulloblastomas are twice as common as those with TP53 mutations and account for approximately 20% of all medulloblastomas. They have an M: F ratio of 1:1. They are most frequently encountered in adults (>16 years) and infants ("
"The hedgehog gene was named in the fruit fly as mutations of this gene leading to loss of function result in the fly embryo being covered in denticles, resembling the spikes of a hedgehog. In mammals, there are three hedgehog genes: Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh) 7."
"When they are of classic or large cell/anaplastic histology and located in the midline, they are essentially indistinguishable from non-WHT/non-SHH group 3 and group 4 tumours 3."
"SHH tumours have an intermediate prognosis compared to other subtypes of medulloblastoma; that is, better than group 3 tumours, but significantly worse than WNT subtypes. Prognosis is also strongly influenced by age 1,4:"
"SHH tumours have an intermediate prognosis compared to other subtypes of medulloblastoma; that is, better than group 3 tumours, but significantly worse than WNT subtypes. Prognosis is also strongly influenced by age 1,4:"