"Mesothelioma is an aggressive malignant tumour of mesothelium and 90% of tumours arise from the pleura. There is a strong association with exposure to asbestos fibres.This article is about the pleural form of the disease, other locations include 17:"
"Typically mesothelioma is a locally-aggressive disease and distant extranodal metastases are uncommon in life15. In a postmortem study of 318 patients, 55% patients were found to have extrathoracic metastases, the commonest sites being the liver (32%), spleen (11%), thyroid (7%) and brain (3%) 16."
"T1: iso to slightly hyperintense cf. muscle 4,6"
"T2: iso to hyperintense cf. muscle 4,6"
"T1 C+ (Gd): enhancement usually present"
"oncogenic simian virus 40 (SV40)"
"BAP1 tumour predisposition syndrome"
Expected headings
"Histology"
"PET"
"Mesothelioma is an aggressive malignant tumour of mesothelium and 90% of tumours arise from the pleura. There is a strong association with exposure to asbestos fibres.This article is about the pleural form of the disease, other locations include 17:"
"Mesothelioma is an uncommon entity and accounts for ~15% (range 5-28%) of all malignancies that involve the pleura 1,7. In cases related to asbestos exposure, 60-80% occur in males and there may be regional hotspots related to local industries, e.g. the historic shipbuilding industry in Belfast, Northern Ireland. There is no convincing evidence for an association with tobacco smoking 6."
"There are three histological types of mesothelioma:"
"para-occupational exposure of household members of asbestos-exposed workers is documented 14,20, with sources of asbestos exposure predominantly being mining, construction, lagging and machinery mechanics"
"inhalational exposure occurs during mining, production and use and the mineral is highly toxic 24"
"Treatment continues to be challenging and the long-term survival is poor. Single modality treatment (surgery, radiotherapy, chemotherapy, immunotherapy and even photodynamic therapy) have not been shown to improve survival 3. Multimodality treatment has had some impact on favourable subgroups (early disease, and epithelioid histology). Treatment includes:"
"+/- pleural effusion; most commonly is unilateral and exudative or haemorrhagic in nature, with frozen hemithorax (not causing mediastinal shift)"
"pleural fibrosis from infective/inflammatory source (e.g. actinomycetes, tuberculosis)"