"Gadolinium-containing contrast agents usually have no effect on blood chemistries and haematologic studies except transient elevation of serum iron and bilirubin levels. These elevations peaked at 4 to 6 hours post-injection and returned to baseline values in 24 to 48 hours. The mechanism of these elevations is uncertain but may be related to mild haemolysis. A 10-11% increase in the activated partial thromboplastin time and thrombin time occurs in vitro with inhibition of platelet aggregation. The platelet aggregation inhibition is less than that seen with iodinated ionic contrast material and no bleeding problems are reported clinically."
"There are reports that repeated administrations of IV gadolinium contrast leads to T1 shortening in the dentate nuclei, and possibly the globus pallidus 3. This is thought to be related to retained gadolinium contrast at these sites. The effect is thought to be more common with linear gadolinium chelates rather than with cyclic chelates 4,5. Gadolinium is deposited in the brain in patients with normal renal function 3. Gadolinium retention is not considered to be related to radiation therapy in patients receiving multiple studies for head and neck cancer 6. The clinical effect of this deposition, if any, is unknown. However, the phenomenon is under investigation by the FDA 7."
"There are reports that repeated administrations of IV gadolinium contrast leads to T1 shortening in the dentate nuclei, and possibly the globus pallidus 3. This is thought to be related to retained gadolinium contrast at these sites. The effect is thought to be more common with linear gadolinium chelates rather than with cyclic chelates 4,5. Gadolinium is deposited in the brain in patients with normal renal function 3. Gadolinium retention is not considered to be related to radiation therapy in patients receiving multiple studies for head and neck cancer 6. The clinical effect of this deposition, if any, is unknown. However, the phenomenon is under investigation by the FDA 7."
Expected headings
"Intravenous gadolinium contrast agent safety"
"Adverse reactions"
"Effect on serum laboratory values"
"Effect on physiology"
"Retained gadolinium"
"Adverse rates for Gd-DTPA are lower than this and comparable to those of gadodiamide and gadoteridol (1.4%-3% for headache, nausea, and dizziness; "
"There are reports that repeated administrations of IV gadolinium contrast leads to T1 shortening in the dentate nuclei, and possibly the globus pallidus 3. This is thought to be related to retained gadolinium contrast at these sites. The effect is thought to be more common with linear gadolinium chelates rather than with cyclic chelates 4,5. Gadolinium is deposited in the brain in patients with normal renal function 3. Gadolinium retention is not considered to be related to radiation therapy in patients receiving multiple studies for head and neck cancer 6. The clinical effect of this deposition, if any, is unknown. However, the phenomenon is under investigation by the FDA 7."