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Lint: multiple-epiphyseal-dysplasia

Citation Preceding Space
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"Widened joint spaces4"

Line 21:28 · Citations must have a preceding space, e.g. needs evidence <sup>2</sup>. '<sup>4</sup>'
Emphasis
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"Although many forms of MED have different genetic and phenotypic expressions, most share the common presentation of joint pain, especially in the hips and knees. Mild to moderate short stature is common, but not mandatory. Muscular hypotonia indicates MED caused by the COMP (cartilage oligomeric matrix protein) gene mutation. Club feet are often associated with the recessive form of the disease (rMED) and are present in nearly a third of individuals with rMED 1."

Line 5:274 · Italics should be used only in exceptional circumstances: '<em>COMP</em>'

"COMP: autosomal dominant, ~50% of the cases"

Line 9:8 · Italics should be used only in exceptional circumstances: '<em>COMP:</em>'

"DTDST (SCL26A2): autosomal recessive, ~25% of the cases"

Line 10:8 · Italics should be used only in exceptional circumstances: '<em>DTDST (SCL26A2):</em>'

"MATN3: autosomal dominant"

Line 11:8 · Italics should be used only in exceptional circumstances: '<em>MATN3:</em>'

"COL9A2: autosomal dominant"

Line 12:8 · Italics should be used only in exceptional circumstances: '<em>COL9A2:</em>'

"COL9A3: autosomal dominant"

Line 13:8 · Italics should be used only in exceptional circumstances: '<em>COL9A3:</em>'

"COL9A1: autosomal dominant, very rare"

Line 14:8 · Italics should be used only in exceptional circumstances: '<em>COL9A1:</em>'
List Caps
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"Widened joint spaces4"

Line 21:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Recency
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"Currently (c. 2024) there are six genetic mutations related to MED 2:"

Line 7:4 · Avoid describing evidence as recent; give a date instead: 'Currently'.