"In 2020, the cIMPACT-NOW Working Committee considered myxoid glioneuronal tumour to represent a distinct entity based on genetic mutations, imaging features and anatomic location; consequently naming it "myxoid glioneuronal tumour, PDGFRA p.K385- mutant" 3 and it is included in the 5th Edition (2021) WHO brain tumour classification 5."
"T2: hyperintense"
"T1 C+ (Gd): no enhancement"
"In 2020, the cIMPACT-NOW Working Committee considered myxoid glioneuronal tumour to represent a distinct entity based on genetic mutations, imaging features and anatomic location; consequently naming it "myxoid glioneuronal tumour, PDGFRA p.K385- mutant" 3 and it is included in the 5th Edition (2021) WHO brain tumour classification 5."
"OLIG2, SOX10, GFAP: positive"
"Myxoid glioneuronal tumour is negative to BRAF and FGFR1 mutations or rearrangements, which distinguish DNETs, rosette-forming glioneuronal tumours (RGNTs) and other low-grade neuroepithelial tumours. Ki-67 index ranges from 1% to 4% 1."
"MRI "
Expected headings
"MRI "
"In 2020, the cIMPACT-NOW Working Committee considered myxoid glioneuronal tumour to represent a distinct entity based on genetic mutations, imaging features and anatomic location; consequently naming it "myxoid glioneuronal tumour, PDGFRA p.K385- mutant" 3 and it is included in the 5th Edition (2021) WHO brain tumour classification 5."
"Although it has been designated as a WHO grade 1 tumour in the WHO brain tumour classification, myxoid glioneuronal tumour tends to recur, progress or disseminate in the ventricles. They may cause critical mass and compressive effect with obstructive hydrocephalus 1."
"Data regarding prognosis for myxoid glioneuronal tumour are limited given the rarity of this entity. Surgical resection is often curative, although cases of recurrence, progression and intraventricular dissemination have been described. In these cases a second resection was frequently necessary. Only seldomly have radiotherapy and chemotherapy been used 1."