"The global incidence of neonatal HSV infection is ~ 10 cases/10,000 live births. Of those cases, ~30% present with CNS disease 6."
"GE/SWI: may demonstrate blooming if haemorrhagic"
"T1 C+ (Gd): enhancement usually presents in a gyriform pattern"
"Neonatal herpes simplex (HSV) encephalitis is a rare but life-threatening infection that at-risk neonates acquire. In contrast to childhood and adult herpes simplex encephalitis, it is commonly related to HSV-2 5."
"Neonatal herpes simplex (HSV) encephalitis is a rare but life-threatening infection that at-risk neonates acquire. In contrast to childhood and adult herpes simplex encephalitis, it is commonly related to HSV-2 5."
"The global incidence of neonatal HSV infection is ~ 10 cases/10,000 live births. Of those cases, ~30% present with CNS disease 6."
"Most cases are due to HSV-2; however, there has been an increase in cases related to HSV-1 5,6."
"Most cases are due to HSV-2; however, there has been an increase in cases related to HSV-1 5,6."
"Detection of HSV in CSF PCR assays confirms the diagnosis, though there have been cases 8 where PCR assays were negative during the early course of the disease. Skin lesions, if present, can also be swabbed for PCR testing 7."
"Detection of HSV in CSF PCR assays confirms the diagnosis, though there have been cases 8 where PCR assays were negative during the early course of the disease. Skin lesions, if present, can also be swabbed for PCR testing 7."
"Detection of HSV in CSF PCR assays confirms the diagnosis, though there have been cases 8 where PCR assays were negative during the early course of the disease. Skin lesions, if present, can also be swabbed for PCR testing 7."
"Detection of HSV in CSF PCR assays confirms the diagnosis, though there have been cases 8 where PCR assays were negative during the early course of the disease. Skin lesions, if present, can also be swabbed for PCR testing 7."
"Clinical manifestations of neonatal HSV infection are classified into three categories 6,7:"
"skin, eye and mouth (SEM) disease ~45%"
"Transmission most commonly occurs during the peripartum period through direct contact with an infected maternal genital tract, followed by the postnatal period through direct contact HSV lesion or with an infected caregiver, and lastly in utero 5."
"Please refer to the pathology section of the herpes simplex encephalitis article for more details on HSV pathogenesis."
"It is important to appreciate that the radiographic appearance of neonatal HSV encephalitis is different from its more common adult counterpart. Changes are typically diffuse which can be difficult to identify due to normal immature myelin (see normal myelination) and more commonly involving the cerebral cortex, the deep white matter, and thalamus 4. The medial temporal and inferior frontal lobes may be spared and haemorrhagic change is uncommon but can develop later and is best seen on gradient echo/susceptibility sequences 1."
"GE/SWI: may demonstrate blooming if haemorrhagic"
"Most cases are due to HSV-2; however, there has been an increase in cases related to HSV-1 5,6."
"skin, eye and mouth (SEM) disease ~45%"
"Symptoms of CNS disease may be non-specific. They include fever, poor feeding, lethargy, seizures or apnoea episodes. Skin lesions will also be found in the majority of patients during their course of illness 7."