"RAS/MAPK pathway"
"Its regulatory behaviour impacts cell growth and proliferation. It mainly acts by regulating the activity of the RAS-family proteins. The neurofibromin protein belongs to a group of proteins called the Ras GTPase-activating proteins (GAP). Their activity is mediated by accelerating the hydrolysis of GTP bound to active RAS protein."
"Its regulatory behaviour impacts cell growth and proliferation. It mainly acts by regulating the activity of the RAS-family proteins. The neurofibromin protein belongs to a group of proteins called the Ras GTPase-activating proteins (GAP). Their activity is mediated by accelerating the hydrolysis of GTP bound to active RAS protein."
"Its regulatory behaviour impacts cell growth and proliferation. It mainly acts by regulating the activity of the RAS-family proteins. The neurofibromin protein belongs to a group of proteins called the Ras GTPase-activating proteins (GAP). Their activity is mediated by accelerating the hydrolysis of GTP bound to active RAS protein."
"interacts with a number of other proteins, e.g. microtubulin, kinesin-1, protein kinase A and C, caveolin and amyloid precursor protein"
"The protein is expressed in all cell types and is predominantly a cytoplasmic protein. However, in some cell types, neurofibromin has been found within the nucleus 1. It predominates in neurones, Schwann cells, oligodendrocytes, astrocytes and leucocytes 2."