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Lint: periorbital-necrotising-fasciitis

Approximation Spacing
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"The most common precipitating event is considered minor penetrating or surgical trauma but in ~25% of cases no trigger can be identified. It can be bilateral in ~ 35% of cases 1."

Line 5:165 · No space after an approximation symbol: '~ 3'.
Citation Preceding Space
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"It usually occurs from infection from beta-haemolytic Streptococcus pyogenes / group A streptococcus. Rarely other organisms such as Pseudomonas aeruginosa 6 and herpes zoster7 have been reported."

Line 6:208 · Citations must have a preceding space, e.g. needs evidence <sup>2</sup>. '<sup>7</sup>'
Emphasis
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"It usually occurs from infection from beta-haemolytic Streptococcus pyogenes / group A streptococcus. Rarely other organisms such as Pseudomonas aeruginosa 6 and herpes zoster7 have been reported."

Line 6:58 · Italics should be used only in exceptional circumstances: '<em>Streptococcus pyogenes</em> / group A streptococcus. Rarely other organisms such as <em>Pseudomonas aeruginosa</em>'