"microscopic polyangiitis: has a much more established association with ANCA and tends to affect smaller arterioles, capillaries and venules"
Expected headings
"Angiography (DSA / CT angiography)"
"systemic signs and symptoms are almost always present and are non-specific, including fever, malaise and weight loss"
"microscopic polyangiitis: has a much more established association with ANCA and tends to affect smaller arterioles, capillaries and venules"
"localised symptoms relate to ischaemia and infarction of affected tissues and organs; the most commonly involved vessels are the renal arteries 1 while the pulmonary circulation is typically spared"
"Initially, there is transmural and necrotising inflammation of medium-sized arteries, mostly involving part of the circumference which causes weakening of the wall leading to microaneurysm formation and subsequent focal rupture. There is a predilection for branch points. Fibrinoid necrosis of vessels promotes thrombosis, which is followed by infarction of the tissue supplied. Fibrous thickening and mononuclear infiltration occur at a later stage. Different stages of inflammation can occur in the same vessel at different points."