"late gadolinium enhancement: a commonly described finding; can be intramyocardial, subepicardial, or subendocardial 9-10"
"Eosinophilic granulomatosis with polyangiitis was first described in 1951 by Jacob Churg (1910-2005), an American pathologist, subspecialising in renal and vascular diseases, and his long-term collaborator and friend Lotte Strauss (1913-1985) an American paediatric pathologist, who were both based at Mount Sinai Hospital in New York City 4,18."
Expected headings
"Diagnostic criteria"
"Eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome is characterised by asthma, eosinophilia and small vessel necrotising vasculitis and involves the lungs and other organs."
"The presence of ANCA has an impact on clinical phenotype, with skin rash, neurological involvement and glomerulonephritis more common in ANCA positive patients, whereas pulmonary, cardiac and gastrointestinal involvement is more common in ANCA negative patients 24."
"The incidence typically peaks in middle age, 30-50 years of age with paediatric cases being rare 2,16,24. The annual incidence rate of around 0.24-1.78 per 100,000 2,16. There is no gender predilection 24."
"tends to be the most frequent feature 1; can be transient"
"late gadolinium enhancement: a commonly described finding; can be intramyocardial, subepicardial, or subendocardial 9-10"
"Corticosteroids (most commonly prednisone) are the mainstay of treatment. Patients with cardiac, renal, gastrointestinal, or CNS involvement, require additional immunosuppression (e.g. ciclosporin, azathioprine)."