"The 1990 American College of Rheumatology criteria requires at least two of the four listed below (sensitivity 88.2% and specificity 92%) 21:"
"Pathology "
"Granulomatosis with polyangiitis (GPA), previously known as Wegener granulomatosis, is a multisystem necrotising non-caseating granulomatous c-ANCA positive vasculitis affecting small to medium-sized arteries, capillaries, and veins, with a predilection for the respiratory system and kidneys."
"In 90% of cases, c-ANCA (PR3) is positive and the levels correlate with disease activity 8."
Expected headings
"Pathology "
"Microscopic appearance"
"Markers"
"There is a slight male predilection, and onset is typically at approximately 50 years of age 8."
"Systemic symptoms such as anorexia, malaise and fever are also common 9."