"The World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) has also published detailed organ-specific criteria (2014) 14."
"Additionally, a positive Kveim-Siltzbach skin test may help confirm the diagnosis, although it is not in routine clinical use and is not FDA-approved 3,16. This test involves intradermal injection of sarcoid-involved splenic material; the test is considered positive when a typical sarcoid granuloma is diagnosed on histology, 4-6 weeks after infection 4,17."
"It is thought to represent a disorder of immune regulation, particularly of cell-mediated immunity 3. RNA and DNA from Mycobacterium and Propionibacterium have been detected in sarcoidosis lesions, raising the possibility of an infectious trigger 4."
"Schaumann bodies: laminated calcium-containing concretions"
"Historically, sarcoidosis was also known as Besnier-Boeck-Schaumann disease/syndrome, or various combinations thereof, e.g. Besnier-Boeck disease, Boeck disease, or Schaumann syndrome 10."
Expected headings
"Complications"
"There is considerable regional variability, with the highest incidence in Northern European (Scandinavian) countries (15 per 100,000), followed by North America and Australia, and the lowest incidence in East Asian countries (0.5-1 per 100,000) 15. Within regions, higher incidences have been reported in Black and African populations than in White, Hispanic, or Asian populations 15."
"Additionally, a positive Kveim-Siltzbach skin test may help confirm the diagnosis, although it is not in routine clinical use and is not FDA-approved 3,16. This test involves intradermal injection of sarcoid-involved splenic material; the test is considered positive when a typical sarcoid granuloma is diagnosed on histology, 4-6 weeks after infection 4,17."
"highly variable; elevated in ~55% (range 30-80%) of patients 18"
"sensitivity ~65% (range 22-86%); specificity ~75% (range 54-95%) 18"
"Otherwise, the radiographic features are organ-dependent; please see individual articles (listed above)."
"Treatment is predominantly aimed at protecting individual organ function and reducing symptom burden, with prudent use of corticosteroids and other immunosuppressive agents (e.g. methotrexate, infliximab) 12,19. Relapse within 1-2 years after treatment withdrawal is relatively common (~60%; range 20-90%) 19."
"stage I: ~75%; range 60-90%"
"stage II: ~55%; range 40-70%"
"stage III: ~15%; range 10-20%"
"Sarcoidosis is derived from the Ancient Greek terms σαρξ (sarc), meaning flesh; ειδος (eidos), meaning form; and σις (-sis), a suffix meaning a process 10,11."
"Sarcoidosis is derived from the Ancient Greek terms σαρξ (sarc), meaning flesh; ειδος (eidos), meaning form; and σις (-sis), a suffix meaning a process 10,11."