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"Pseudoxanthoma elasticum (PXE), also known as Grönblad–Strandberg syndrome, is a rare heritable systemic condition characterised by the degeneration of elastic fibres. It has a wide range of multiorgan manifestations."

Line 1:83 · Use a hyphen-minus ('-') instead of an en-dash ('–').

Headings Spacing

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"Genetics "

Line 44:1 · Never put spaces at either end of headings.

Biographical Date Spacing

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"It was first described in 1881 by D Rigal⁸. The first complete description of the syndrome was by Swedish ophthalmologist Ester E (Elisabeth) Grönblad (1898-1942) ^13,14 and Swedish dermatologist James V (Victor) Strandberg (1883-1942) ¹³."

Line 55:38 · In a biographical citation, the date should be correctly spaced: 'D Rigal 8. The first complete description of the syndrome was by Swedish ophthalmologist Ester E (Elisabeth) Grönblad (1898-1942) 13,14 and Swedish dermatologist James V (Victor) Strandberg (1883'

Emphasis

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"Pseudoxanthoma elasticum is the result of mutations in the ABCC6 (ATP-binding cassette subfamily C member 6) gene (short art chromosome 16), which encodes a transmembrane ATP binding efflux transporter¹⁵."

Line 45:63 · Italics should be used only in exceptional circumstances: 'ABCC6'

Acronyms

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"Pseudoxanthoma elasticum is the result of mutations in the ABCC6 (ATP-binding cassette subfamily C member 6) gene (short art chromosome 16), which encodes a transmembrane ATP binding efflux transporter¹⁵."

Line 45:79 · 'ATP' has no definition. Spell it out if it's unfamiliar to the audience.

"Pseudoxanthoma elasticum is the result of mutations in the ABCC6 (ATP-binding cassette subfamily C member 6) gene (short art chromosome 16), which encodes a transmembrane ATP binding efflux transporter¹⁵."

Line 45:184 · 'ATP' has no definition. Spell it out if it's unfamiliar to the audience.

Headings Valid

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Expected headings

H1 Terminology
H1 Usage
H1 Epidemiology
H2 Risk factors
H2 Associations
H1 Clinical presentation
H2 Complications
H1 Diagnosis
H2 Diagnostic criteria
H2 Diagnostic clues
H1 Pathology
H2 Aetiology
H2 Location
H2 Classification
H2 Macroscopic appearance
H2 Microscopic appearance
H2 Immunophenotype
H2 Markers
H2 Genetics
H1 Radiographic features
H2 Plain radiograph
H2 Mammography
H2 Antenatal ultrasound
H2 Transoesophageal echocardiography
H2 Ultrasound
H2 CT
H3 Dual-energy CT
H2 Angiography (DSA)
H2 MRI
H2 CT/MRI
H2 Nuclear medicine
H3 PET-CT
H3 PET-MRI
H1 Radiology report
H1 Treatment and prognosis
H2 Complications
H1 History and etymology
H1 Differential diagnosis
H2 Clinical differential diagnosis
H1 Practical points
H1 See also

"Genetics "

Line 44:1 · "Genetics " is not a recognised heading for this article type.

Inline EG

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"solid organ mineralisation (e.g. adrenal gland)"

Line 50:35 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.

"sequelae of ischaemia (e.g. leukoaraiosis ¹)"

Line 52:30 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.

Parentheses

suggestion

"It was first described in 1881 by D Rigal⁸. The first complete description of the syndrome was by Swedish ophthalmologist Ester E (Elisabeth) Grönblad (1898-1942) ^13,14 and Swedish dermatologist James V (Victor) Strandberg (1883-1942) ¹³."

Line 55:171 · Use parentheses judiciously. There are at least 3 sets in this paragraph.

Lint: pseudoxanthoma-elasticum