Radiopaedia Helpers

Strong

warning

"Broadly, RASopathies can be described as being caused by germline (germline RASopathies) or somatic mutations ⁸. The term mosaic RASopathies is often used to describe RASopathy syndromes due to somatic mutations, but this entity has a variable definition in the literature, encompassing syndromes caused by somatic mutations ('true' mosaic RASopahies) affecting the Ras/MAPK pathway, isolated malformations due to somatic mutations affecting the Ras/MAPK pathway, and mosaic forms of germline RASopathies ⁸."

Line 2:71 · Generally, don't use bold in text: '<strong>germline RASopathies</strong>'

"Broadly, RASopathies can be described as being caused by germline (germline RASopathies) or somatic mutations ⁸. The term mosaic RASopathies is often used to describe RASopathy syndromes due to somatic mutations, but this entity has a variable definition in the literature, encompassing syndromes caused by somatic mutations ('true' mosaic RASopahies) affecting the Ras/MAPK pathway, isolated malformations due to somatic mutations affecting the Ras/MAPK pathway, and mosaic forms of germline RASopathies ⁸."

Line 2:154 · Generally, don't use bold in text: '<strong>mosaic RASopathies</strong>'

Acronyms

warning

"cardiofaciocutaneous syndrome: an autosomal dominant Noonan-like disorder caused by a germline mutation to one of many possible genes, the most common being the BRAF gene which encodes for BRAF, an oncoprotein, which when dysfunctional results in increased signalling of the Ras/MAPK pathway ^1-3"

Line 38:216 · 'BRAF' has no definition. Spell it out if it's unfamiliar to the audience.

"Costello syndrome: an autosomal dominant Noonan-like disorder caused by a germline mutation to the HRAS gene which encodes for HRAS, which when dysfunctional results in increased signalling of the Ras/MAPK pathway ^1-3"

Line 40:147 · 'HRAS' has no definition. Spell it out if it's unfamiliar to the audience.

Headings Valid

warning

Expected headings

H1 Terminology
H1 Usage
H1 Epidemiology
H2 Risk factors
H2 Associations
H1 Clinical presentation
H2 Complications
H1 Diagnosis
H2 Diagnostic criteria
H2 Diagnostic clues
H1 Pathology
H2 Aetiology
H2 Location
H2 Classification
H2 Macroscopic appearance
H2 Microscopic appearance
H2 Immunophenotype
H2 Markers
H2 Genetics
H1 Radiographic features
H2 Plain radiograph
H2 Mammography
H2 Antenatal ultrasound
H2 Transoesophageal echocardiography
H2 Ultrasound
H2 CT
H3 Dual-energy CT
H2 Angiography (DSA)
H2 MRI
H2 CT/MRI
H2 Nuclear medicine
H3 PET-CT
H3 PET-MRI
H1 Radiology report
H1 Treatment and prognosis
H2 Complications
H1 History and etymology
H1 Differential diagnosis
H2 Clinical differential diagnosis
H1 Practical points
H1 See also

"Germline RASopathy syndromes"

Line 23:1 · "Germline RASopathy syndromes" is not a recognised heading for this article type.

"Mosaic RASopathy syndromes"

Line 47:1 · "Mosaic RASopathy syndromes" is not a recognised heading for this article type.

Inline EG

suggestion

"cutaneous anomalies (e.g. café au lait spots)"

Line 10:28 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.

Commas

suggestion

"Noonan syndrome: autosomal dominant disorder caused by a germline mutation to one of many possible genes, the most common being the PTPN11 gene which encodes for SHP2, which results in an inability to inactivate SHP2 causing increased signalling of the Ras/MAPK pathway; other genes that may be implicated include SOS1, KRAS, RAF1, NRAS, and SHOC2 ^1-3"

Line 31:115 · More than 5 commas in a single sentence might make it more difficult to read.

Semicolons

suggestion

"Noonan syndrome: autosomal dominant disorder caused by a germline mutation to one of many possible genes, the most common being the PTPN11 gene which encodes for SHP2, which results in an inability to inactivate SHP2 causing increased signalling of the Ras/MAPK pathway; other genes that may be implicated include SOS1, KRAS, RAF1, NRAS, and SHOC2 ^1-3"

Line 31:289 · Use semicolons judiciously.

Oxford Comma

suggestion

"cutaneous skeletal hypophosphataemia syndrome: due to somatic mutations in HRAS, NRAS or FGFR1 ⁸"

Line 49:94 · Use the Oxford comma in 'HRAS, NRAS or FGFR1'.

Lint: rasopathy-1