"Pathology "
"Radiographic features "
"T1 C+ (Gd): contrast enhancement of the meninges can occur"
"High serum thyroid peroxidase antibody levels (anti-TPO or TPOAb >200 UI/mL) are required for the diagnosis. However, this marker is not specific for the disease as many healthy persons and patients with other encephalitides test positive for this antibody 2."
"High serum thyroid peroxidase antibody levels (anti-TPO or TPOAb >200 UI/mL) are required for the diagnosis. However, this marker is not specific for the disease as many healthy persons and patients with other encephalitides test positive for this antibody 2."
Expected headings
"Pathology "
"Markers"
"Radiographic features "
"Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also known as Hashimoto encephalopathy, is a rare syndrome associated with autoimmune thyroid disease, characterised by a wide range of neuropsychiatric symptoms, normal or nonspecific brain MRI findings, and elevated serum thyroid peroxidase antibodies regardless of thyroid functional status. Pretreatment diagnostic criteria are not specific but clinical responsiveness to glucocorticoid treatment and exclusion of other causes of encephalitis can confirm the diagnosis."
"Patients present with a wide range of neurologic symptoms, including subacute or fluctuating cognitive impairment or decreased level of consciousness, seizures or new onset status epilepticus, movement disorders (myoclonus, rigidity, cerebellar ataxia, or dyskinesias), or psychiatric disorders (psychosis, depression, tics, or obsessive-compulsive disorder) 1,2,4."
"Patients present with a wide range of neurologic symptoms, including subacute or fluctuating cognitive impairment or decreased level of consciousness, seizures or new onset status epilepticus, movement disorders (myoclonus, rigidity, cerebellar ataxia, or dyskinesias), or psychiatric disorders (psychosis, depression, tics, or obsessive-compulsive disorder) 1,2,4."
"Patients may have mild clinical or subclinical hypothyroidism (elevated serum thyroid-stimulating hormone (TSH) and normal or low serum free thyroxine (T4) levels) 2. However, it is common to have normal thyroid function (normal serum TSH) at the time of neurologic presentation 3. Association with hyperthyroidism (low TSH) is least common 7,8."