"The biphasic variant is composed of glandular components (which may be dominant or hidden) and spindle cells. Spindle cells are quite uniform and arranged in fascicular pattern."
"Treatment involves a combination of surgery and usually adjuvant radiotherapy +/- chemotherapy. Radiotherapy is particularly useful in treating tumours where an adequate clear margin cannot be achieved, and ideally, radiotherapy is administered pre-operatively."
"Monophasic synovial sarcoma composed of spindle cells and is quite resemble to MPNST, fibrosarcoma, mesenchymal chondrosarcoma and cellular SFT. For establishing a correct diagnosis, an IHC study for keratin and EMA is very helpful. Nearly 90% of monophasic variants are at least focally positive for keratin or EMA."
"Monophasic synovial sarcoma composed of spindle cells and is quite resemble to MPNST, fibrosarcoma, mesenchymal chondrosarcoma and cellular SFT. For establishing a correct diagnosis, an IHC study for keratin and EMA is very helpful. Nearly 90% of monophasic variants are at least focally positive for keratin or EMA."
"Monophasic synovial sarcoma composed of spindle cells and is quite resemble to MPNST, fibrosarcoma, mesenchymal chondrosarcoma and cellular SFT. For establishing a correct diagnosis, an IHC study for keratin and EMA is very helpful. Nearly 90% of monophasic variants are at least focally positive for keratin or EMA."
"SS18-SSX fusion antibody is 95% sensitive and specific for synovial sarcoma.10"
"The most common location for these tumours is within the deep soft tissues adjacent to large joints, e.g. knee and popliteal fossa. While these tumours arise near joints, it is rare for them to arise from the joint itself and despite their name, they do not arise from synovial structures, e.g. joints, tendon sheaths and bursae."
"Non-specific findings, with a heterogeneous predominantly hypoechoic mass. Intra-lesion flow is usually associated with more aggressive lesions."
"Overall 5-year survival is between 36-76%. Both local recurrence (30-50%) and distant metastases are frequent (40-70%), most commonly to the lungs as cannonball metastases (~80%), bones (~15%), regional lymph nodes (~10%), followed by chest wall/abdomen (~7.5%) 7,8."
"lung 2, kidney, prostate, oesophagus, heart, pericardium, pleura"