"sestamibi is stabilised by using copper tetrafluoroborate during storage conditions. During labelling, sestamibi is heated to remove the copper tetrafluoroborate 4."
"indications: investigation of chest pain, suspicion of coronary artery disease, pre-surgical workup including prior to renal transplantation"
"Myocardial perfusion scintigraphy is performed with both rest and stress phases, looking for areas of reversible ischaemia (exercise stress) or impaired myocardial flow reserve (pharmacologic stress). Rest imaging is usually performed first, with a stress phase conducted on the same day with a higher dose injection or a subsequent day."
"Myocardial perfusion scintigraphy is performed with both rest and stress phases, looking for areas of reversible ischaemia (exercise stress) or impaired myocardial flow reserve (pharmacologic stress). Rest imaging is usually performed first, with a stress phase conducted on the same day with a higher dose injection or a subsequent day."
Expected headings
"Characteristics"
"Uses, doses and timings"
"Parathyroid scan"
"Myocardial perfusion scintigraphy"
"brain uptake depends on blood-brain barrier (BBB) rupture; correlates with cell proliferation indices (Ki67)"
"timing: early scan at 15 min; delayed scan at 2 hours"
"When the radiopharmaceutical is used for parathyroid imaging, immediate and delayed imaging of the neck and mediastinum is performed; parathyroid adenomas are best demonstrated on delayed imaging (1-2 hours). A thyroid scan using Tc-99m pertechnetate follows. Parathyroid adenomas do not demonstrate uptake on thyroid scans, whereas normal thyroid tissue does."
"Tc-99m-sestamibi is a radiopharmaceutical that is taken up by cells with a high concentration of mitochondria i.e. highly cellular/metabolically active tissues such as the myocardium of the heart, but also abnormal tissues such as oxyphil cell parathyroid adenomas, myeloma and breast cancer (the basis of so-called scintimammography). This latter technique has a high specificity for cancer but uses significant radiation dose."
"Uses, doses and timings"
"When the radiopharmaceutical is used for parathyroid imaging, immediate and delayed imaging of the neck and mediastinum is performed; parathyroid adenomas are best demonstrated on delayed imaging (1-2 hours). A thyroid scan using Tc-99m pertechnetate follows. Parathyroid adenomas do not demonstrate uptake on thyroid scans, whereas normal thyroid tissue does."
"A pharmacological stress test involves the infusion of a coronary vasodilator such as adenosine, persantin or regadenoson. Each drug has a unique infusion protocol. Caffeine is contraindicated for 24 hours prior to persantin and adenosine studies. Pharmacological stress testing examines coronary flow reserve, with diseased coronary vessels having impaired physiological response to the infused medication. Other territories of the heart with normal flow will have a relatively higher amount of Tc-99m tracer than those supplied by the diseased vessel."