"The trilaminar sign, also known as the tricolour sign, is a radiological sign characteristically seen in MRI brain of acute necrotising encephalopathy (of childhood) (ANEC)."
"This pattern is characteristically described in acute necrotising encephalopathy (of childhood) (ANEC) and is thought to be due to a combination of vasogenic oedema accounting of the high signal outermost ring, cytotoxic oedema accounting for the low signal middle ring (i.e. true restricted diffusion), and haemorrhage accounting for the central high signal region 2,3. In one small case series of six patients with acute necrotising encephalopathy (of childhood) (ANEC), the sign was present in all patients reviewed 1."
"This pattern is characteristically described in acute necrotising encephalopathy (of childhood) (ANEC) and is thought to be due to a combination of vasogenic oedema accounting of the high signal outermost ring, cytotoxic oedema accounting for the low signal middle ring (i.e. true restricted diffusion), and haemorrhage accounting for the central high signal region 2,3. In one small case series of six patients with acute necrotising encephalopathy (of childhood) (ANEC), the sign was present in all patients reviewed 1."
"This pattern is characteristically described in acute necrotising encephalopathy (of childhood) (ANEC) and is thought to be due to a combination of vasogenic oedema accounting of the high signal outermost ring, cytotoxic oedema accounting for the low signal middle ring (i.e. true restricted diffusion), and haemorrhage accounting for the central high signal region 2,3. In one small case series of six patients with acute necrotising encephalopathy (of childhood) (ANEC), the sign was present in all patients reviewed 1."