"The aetiology and the pathogenesis of acute necrotising encephalitis are only partially clear. Usually, it develops secondary to viral infections, including influenza A and influenza B, parainfluenza, varicella, enterovirus, and SARS-CoV-2 9."
"Acute necrotising encephalopathy, also referred as acute necrotising encephalopathy of childhood (ANEC), is a rare type of encephalopathy characterised by multiple bilateral brain lesions, mainly involving the thalami, but also the putamina, internal and external capsules, cerebellar white matter, and the brainstem tegmentum."
"The aetiology and the pathogenesis of acute necrotising encephalitis are only partially clear. Usually, it develops secondary to viral infections, including influenza A and influenza B, parainfluenza, varicella, enterovirus, and SARS-CoV-2 9."
"Acute necrotising encephalopathy, also referred as acute necrotising encephalopathy of childhood (ANEC), is a rare type of encephalopathy characterised by multiple bilateral brain lesions, mainly involving the thalami, but also the putamina, internal and external capsules, cerebellar white matter, and the brainstem tegmentum."
"Pathologically, the lesions show oedema, haemorrhage and necrosis. Acute necrotising encephalopathy is characterised by the lack of inflammatory cells in affected brain parenchyma in comparison to the more common entities of acute disseminated encephalomyelitis and acute haemorrhagic encephalitis 1."
"On CT, the corresponding thalamic, putamina, cerebral, cerebellar and brainstem abnormalities are hypodense."
"associated with hypoglycaemia, hyperammonaemia and lactic acidosis"
"associated with hypoglycaemia, hyperammonaemia and lactic acidosis"
"Acute necrotising encephalitis is a rare condition. From the first case described in 1995, many cases have been reported in Asia as well as in many Western countries. Most cases are sporadic; however, a few cases of recurrent and/or familial episodes have been reported, secondary to mutations in the RANBP2 gene 10."
"Clinically, it is characterised by acute encephalopathy, with dramatic neurological deficits/symptoms. A viral aetiology has been proposed in some cases; viral prodrome may therefore precede the neurological deficits."
"Acute necrotising encephalitis carries a very poor prognosis; the mortality rate is near 70%. Treatment is mainly supportive, as the precise aetiology remains unknown."