"Diagnosis "
"Whipple disease is a rare infectious multisystem disorder caused by the Actinomycota Tropheryma whipplei."
"T. whipplei is present in ~5% (range 1-10%) of healthy individuals with genetic and immune factors thought to be important, as only 0.01% of infected individuals will develop Whipple disease 10."
Expected headings
"Diagnosis "
"The incidence of Whipple disease is not known; one Swiss study estimated it at approximately 1 per 1.5 million per year 7."
"Patients often present with a non-destructive migratory arthritis, weight loss, diarrhoea and abdominal pain. Less commonly, patients present with fever, lymphadenopathy or hepatosplenomegaly 5. The presence of arthritis may precede other symptoms by years 8."
"Patients often present with a non-destructive migratory arthritis, weight loss, diarrhoea and abdominal pain. Less commonly, patients present with fever, lymphadenopathy or hepatosplenomegaly 5. The presence of arthritis may precede other symptoms by years 8."
"The small bowel (intestinal lipodystrophy) is a classic location, although the disease can affect multiple other organ systems, with or without small bowel involvement. Other locations include 1,2:"