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Lint: wilson-disease-2

Headings Spacing
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"Treatment and prognosis "

Line 55:1 · Never put spaces at either end of headings.
Biographical Date Spacing
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"It was initially described by Samuel Alexander Kinnier Wilson (1878-1937), an American-born British neurologist, in 1912 as "progressive lenticular degeneration". Wilson also coined the terms extrapyramidal system and syndrome 10,20. Interestingly, Kayser-Fleischer rings were initially described a decade earlier by German physicians Bernhard Kayser (1869-1954) and Bruno Fleischer (1848-1904) in 1902 and 1903 respectively 16,17,21."

Line 71:34 · In a biographical citation, the date should be correctly spaced: '<strong>Samuel Alexander Kinnier Wilson </strong>(1878'
Acronyms
warning

"elevated bilirubin, AST and ALT"

Line 8:28 · 'AST' has no definition. Spell it out if it's unfamiliar to the audience.

"elevated bilirubin, AST and ALT"

Line 8:36 · 'ALT' has no definition. Spell it out if it's unfamiliar to the audience.
List Caps
warning

"Kayser-Fleischer rings in Descemet membrane of the peripheral cornea 11, characteristic but not pathognomonic"

Line 29:11 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Emphasis
warning

"Wilson disease is caused by one of many mutations of the ATP7B gene on the long arm of chromosome 13 which codes for the ATP7B enzyme that enables biliary excretion of excess copper, normally accounting for 95% of copper excretion. Copper first accumulates in the liver, generating free radicals and causing oxidative damage to proteins and lipids, with early damage to mitochondria, nuclei and peroxisomes."

Line 45:61 · Italics should be used only in exceptional circumstances: '<em>ATP7B </em>'
Headings Valid
warning

Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Treatment and prognosis "

Line 55:1 · "Treatment and prognosis " is not a recognised heading for this article type.
Oxford Comma
suggestion

"Wilson disease, also known as hepatolenticular degeneration, is a rare and potentially fatal autosomal recessive disorder caused by impairment of both biliary copper excretion and serum copper transport. Copper first accumulates in the liver causing slowly progressive disease and subsequently spills over into the bloodstream causing oxidative damage to the brain, kidneys and other organs. The range of manifestations and phenotypes adds to the diagnostic challenge."

Line 1:404 · Use the Oxford comma in 'brain, kidneys and other'.

"elevated bilirubin, AST and ALT"

Line 8:17 · Use the Oxford comma in 'bilirubin, AST and ALT'.

"Wilson disease is caused by one of many mutations of the ATP7B gene on the long arm of chromosome 13 which codes for the ATP7B enzyme that enables biliary excretion of excess copper, normally accounting for 95% of copper excretion. Copper first accumulates in the liver, generating free radicals and causing oxidative damage to proteins and lipids, with early damage to mitochondria, nuclei and peroxisomes."

Line 45:383 · Use the Oxford comma in 'mitochondria, nuclei and peroxisomes'.