"Alveolar soft part sarcoma is highly malignant, with a relatively indolent, yet relentless course. The overall prognosis is poor given the high frequency of metastatic disease 1. A large study indicated that the median survival time was 3 years if metastatic disease was present at diagnosis and 11 years without metastatic disease at presentation 2,4. Another study showed survival rates of 77% at 2 years, 60% at 5 years, 38% at 10 years and only 15% at 20 years 10."
"The cells are PAS-positive with diastase-resistant intracytoplasmic inclusions 1."
"vascular malformations (e.g. AVM): demonstrates pure vascular tissue and no accompanying solid tumour 3"
"There is strong strong nuclear staining by an antibody directed against the C‐terminus of the transcription factor E3 (TFE3) gene, which shows sensitivity and specificity of 92% for ASPS 11."
"There is a slight female predilection in patients less than 30 years old 1. They account for"
"There is strong strong nuclear staining by an antibody directed against the C‐terminus of the transcription factor E3 (TFE3) gene, which shows sensitivity and specificity of 92% for ASPS 11."
"ASPS derives its name from its histological appearance 1. It is characterised by well-defined nests of large, round or polygonal tumour cells with generous eosinophilic cytoplasm, separated by fibrous stroma 7. They are arranged in the classic alveolar growth pattern with minimal to no mitotic figures. Vascular invasion is a common feature."
"synovial sarcoma: slow-growing and superficial tumour, without flow voids on MRI, and with calcification, necrosis and haemorrhage often noted on CT 3"
"T2 hyperintense; associated vascular signal voids are common secondary to large peritumoral blood vessels"