"T1: iso- to hypointense"
"T1 C+ (Gd): heterogeneous enhancement"
"intermediate ADC values of the solid component (1190 to 1250 x 10-6 mm2/s) 8"
"The presence of MN1 alterations (a transcriptional coregulator involved in the development of acute myeloid leukaemia and meningiomas) is now used to define the lesion, and thus it is now named astroblastoma, MN1-altered and considered circumscribed astrocytic gliomas in the 5th edition (2021) WHO classification of CNS tumours 6."
"They occur at all ages, ranging from early childhood to the sixth decade but are most commonly seen in children, adolescents, and young adults with a mean age between 10-30 years 2,5. A strong female predilection has been suggested in some reports 5,6."
"Astroblastomas have elongated glial cells with abundant eosinophilic cytoplasm and a broad, or “stout”, GFAP positive process extending radially towards a central blood vessel, forming "astroblastic pseudorosettes", reminiscent to the perivascular pseudorosettes of ependymomas, which are a characteristic feature of this tumour. The central vessel tends to be hyalinized."
"GFAP: positive"
"EMA (cell membrane): variable"
"astrocytoma, particularly GBM or gemistocytic"