"these mostly affects the torso and extremities and can be made of elastin or collagen fibres or may be entirely fibrous."
"cutaneous manifestations: small connective tissue naevi also called dermatofibrosis lenticularis disseminata"
"It is caused by a loss‐of‐function mutation in LEMD3 at 12q14 (OMIM 607844). The exact mechanism by which LEMD3 causes lesions is not yet understood (c. 2019) . This gene codes for the inner nuclear membrane protein, LEMD3, which interacts with both the BMP and TGF-beta signalling pathways 5."
"It is caused by a loss‐of‐function mutation in LEMD3 at 12q14 (OMIM 607844). The exact mechanism by which LEMD3 causes lesions is not yet understood (c. 2019) . This gene codes for the inner nuclear membrane protein, LEMD3, which interacts with both the BMP and TGF-beta signalling pathways 5."
"It is caused by a loss‐of‐function mutation in LEMD3 at 12q14 (OMIM 607844). The exact mechanism by which LEMD3 causes lesions is not yet understood (c. 2019) . This gene codes for the inner nuclear membrane protein, LEMD3, which interacts with both the BMP and TGF-beta signalling pathways 5."
"It is caused by a loss‐of‐function mutation in LEMD3 at 12q14 (OMIM 607844). The exact mechanism by which LEMD3 causes lesions is not yet understood (c. 2019) . This gene codes for the inner nuclear membrane protein, LEMD3, which interacts with both the BMP and TGF-beta signalling pathways 5."
"It is caused by a loss‐of‐function mutation in LEMD3 at 12q14 (OMIM 607844). The exact mechanism by which LEMD3 causes lesions is not yet understood (c. 2019) . This gene codes for the inner nuclear membrane protein, LEMD3, which interacts with both the BMP and TGF-beta signalling pathways 5."
"Helene Ollendorff Curth: German-American dermatologist (1899-1982), Ollendorf was her maiden name 2"
"Abraham Buschke: German dermatologist (1868-1943) 3"
"Hans Theodor Schreus: German dermatologist and radiologist (1892-1970) ref"
"a leading cause of mortality is the development of areas of bone density into osteosarcoma, chondrosarcoma or giant cell tumours ref"