"Carney complex can be familial (70%) or as a sporadic de novo mutation (30%) 8-10. When familial, Carney complex has autosomal dominant inheritance with ~85% (range 70-100%) penetrance 5,6,8. Carney complex is related to inactivating mutations or large deletions of the PRKAR1A tumour suppressor gene on chromosome 17q22-24 5,6 or chromosome 2p16 8."
"There are other multiple endocrine neoplasia syndromes and these are discussed separately."
"Cushing syndrome: most common endocrine presentation; related to primary pigmented nodular adrenocortical disease (PPNAD)"
"cardiac myxoma (~45%; range 20-67%): often multiple 1-4,10"