"A significant minority of carotid body tumours are hereditary, with familial rates of approximately 30-40% reported in contemporary series; multicentric disease is common in this setting (35–50%) 1,3,15,16. Other risk factors include residence at high altitude (>2,000 m) 6."
"larger and show moderate arterial attachment."
"Pre-operative embolisation has been performed, particularly in larger tumours, primarily aiming to reduce intraoperative blood loss, although its use is heterogeneous, with some centres safely removing even larger tumours without embolisation 10."
"PET/CT with Gallium-68 DOTATATE is now considered the first-line functional modality, superseding Octreoscan 12-14. It is effective at identifying both metastatic disease and multifocal disease 14."
"FDG-PET/CT is useful to assess for the presence of metastatic disease 14."
"SDHD and SDHAF2: highest risk for multifocal head and neck paragangliomas"
"SDHB: is less common but has the highest metastatic risk"
"Wnt-altered clusters"
"The Shamblin classification proposed in 1971 7 remains the most widely used classification for carotid body tumours and was based on catheter angiography but can easily be applied to CT and MRI 4. It predicts the ease of resection, need for vascular reconstruction and how much intra-operative blood loss is to be expected 4,7,14."
Expected headings
"Classification"
"A significant minority of carotid body tumours are hereditary, with familial rates of approximately 30-40% reported in contemporary series; multicentric disease is common in this setting (35–50%) 1,3,15,16. Other risk factors include residence at high altitude (>2,000 m) 6."
"vagal schwannoma: spreads the ICA and internal jugular vein; displaces the ICA anteromedially 5"
"Cranial nerves that travel in the carotid sheath (glossopharyngeal, vagus, accessory and hypoglossal nerves) may be involved. Associated symptoms relate to their dysfunction 2."
"Malignant carotid body tumours, most often Shamblin group III tumours, with metastases most commonly to regional lymph nodes, bone, lung and liver and 3,9,15,17."
"Malignant carotid body tumours, most often Shamblin group III tumours, with metastases most commonly to regional lymph nodes, bone, lung and liver and 3,9,15,17."