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Lint: succinate-dehydrogenase-sdhx-gene-mutation

succinate-dehydrogenase-sdhx-gene-mutation
Acronyms
warning

"There are four SDH genes - SDHA, SDHB, SDHC, SDHD (collectively called SDHx) - which encode the four protein subunits of the SDH mitochondrial enzyme 6,7. In addition, SDHAF2 is needed for SDHA protein flavination 7."

Line 3:19 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"There are four SDH genes - SDHA, SDHB, SDHC, SDHD (collectively called SDHx) - which encode the four protein subunits of the SDH mitochondrial enzyme 6,7. In addition, SDHAF2 is needed for SDHA protein flavination 7."

Line 3:183 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"There are four SDH genes - SDHA, SDHB, SDHC, SDHD (collectively called SDHx) - which encode the four protein subunits of the SDH mitochondrial enzyme 6,7. In addition, SDHAF2 is needed for SDHA protein flavination 7."

Line 3:258 · 'SDHA' has no definition. Spell it out if it's unfamiliar to the audience.

"In the citric acid cycle, SDH converts succinate to fumarate. Mutations in any one of the SDHx genes can result in mitochondrial dysfunction (SDH-deficiency) leading to neoplasia 6,7:"

Line 4:30 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"In the citric acid cycle, SDH converts succinate to fumarate. Mutations in any one of the SDHx genes can result in mitochondrial dysfunction (SDH-deficiency) leading to neoplasia 6,7:"

Line 4:155 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"associated with SDH-deficient GIST"

Line 10:24 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"common in SDH-deficient RCC"

Line 17:18 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"common in SDH-deficient RCC"

Line 27:18 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"lower penetrance than SDHD mutation"

Line 28:30 · 'SDHD' has no definition. Spell it out if it's unfamiliar to the audience.

"associated with SDH-deficient GIST"

Line 33:28 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.

"PitNET/pituitary adenoma: SDH-deficiency in"

Line 45:41 · 'SDH' has no definition. Spell it out if it's unfamiliar to the audience.
Emphasis
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"There are four SDH genes - SDHA, SDHB, SDHC, SDHD (collectively called SDHx) - which encode the four protein subunits of the SDH mitochondrial enzyme 6,7. In addition, SDHAF2 is needed for SDHA protein flavination 7."

Line 3:31 · Italics should be used only in exceptional circumstances: '<em>SDHA</em>, <em>SDHB</em>, <em>SDHC</em>, <em>SDHD </em>(collectively called <em>SDHx</em>)<em> </em>'

"In the citric acid cycle, SDH converts succinate to fumarate. Mutations in any one of the SDHx genes can result in mitochondrial dysfunction (SDH-deficiency) leading to neoplasia 6,7:"

Line 4:94 · Italics should be used only in exceptional circumstances: '<em>SDHx </em>'

"SDHA mutation"

Line 7:4 · Italics should be used only in exceptional circumstances: '<em>SDHA </em>'

"SDHB mutation"

Line 14:4 · Italics should be used only in exceptional circumstances: '<em>SDHB </em>'

"SDHC epimutation (promotor hypermethylation)"

Line 32:4 · Italics should be used only in exceptional circumstances: '<em>SDHC </em>'

"SDHD mutation"

Line 36:4 · Italics should be used only in exceptional circumstances: '<em>SDHD </em>'

"Asymptomatic SDHx carriers should undergo clinical and biochemical screening from childhood 6. MRI is recommended for childhood screening, and MRI and PET-CT recommended for adulthood screening 6."

Line 49:17 · Italics should be used only in exceptional circumstances: '<em>SDHx</em>'
List Caps
warning

"PitNET/pituitary adenoma: SDH-deficiency in"

Line 45:11 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Headings Valid
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Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Associations"

Line 43:1 · "Associations" is under the wrong parent heading (found under "Pathology").
Oxford Comma
suggestion

"Succinate dehydrogenase gene (SDHx) germline mutations increase the risk of sympathetic paragangliomas, head and neck paragangliomas, phaeochromocytomas, renal cell carcinoma (RCC), and gastric gastrointestinal stromal tumours (GIST) 1,2,6,7."

Line 1:112 · Use the Oxford comma in 'paragangliomas, head and neck'.
Commas
suggestion

"Succinate dehydrogenase gene (SDHx) germline mutations increase the risk of sympathetic paragangliomas, head and neck paragangliomas, phaeochromocytomas, renal cell carcinoma (RCC), and gastric gastrointestinal stromal tumours (GIST) 1,2,6,7."

Line 1:130 · More than 5 commas in a single sentence might make it more difficult to read.
There Is
suggestion

"There are four SDH genes - SDHA, SDHB, SDHC, SDHD (collectively called SDHx) - which encode the four protein subunits of the SDH mitochondrial enzyme 6,7. In addition, SDHAF2 is needed for SDHA protein flavination 7."

Line 3:4 · Don't start a sentence with 'There are'.
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