"abnormal post-migration cortical organisation"
"post-migrational microcephaly"
"Abnormal cell proliferation or apoptosis "
"Generalised transmantle migration abnormalities "
"This first group of conditions include those due to disorders of neuronal and/or glial proliferation or apoptosis. They can conceptually be further divided into three subgroups; those with abnormally small brain size, those with abnormally large and those with cortical dysgenesis with abnormal cells (neoplastic or non-neoplastic) 7,8,."
Expected headings
"Abnormal cell proliferation or apoptosis "
"Small brain size"
"Large brain size"
"Cortical dysgenesis with abnormal cells"
"Non-neoplastic"
"Neoplastic"
"Abnormal neuronal migration"
"Neuroependymal malformations"
"Generalised transmantle migration abnormalities "
"Localised transmantle migration abnormalities"
"Abnormal terminal migration"
"Abnormal post migrational development"
"Prior classifications (up to and including 2012) attempted a fairly stringent classification into groups and subgroups 7. Many conditions, however, did not neatly fit within such a rigid framework. As more evidence for the specific genetic and pathophysiological underpinnings emerges, there has been a move away from such a formal classification. The most recent (2020) classification uses a far more flexible framework, acknowledging the aforementioned three main mechanisms but largely eliminating a formal classification structure; rather it gives an overview and then goes into defining individual conditions 8."
"This first group of conditions include those due to disorders of neuronal and/or glial proliferation or apoptosis. They can conceptually be further divided into three subgroups; those with abnormally small brain size, those with abnormally large and those with cortical dysgenesis with abnormal cells (neoplastic or non-neoplastic) 7,8,."