"perisylvian: ~ 60%"
"Polymicrogyria may be genetic (sporadic or with heterogenous inheritance patterns), or secondary to infection, metabolic, or vascular causes (listed below). Over 50 genes have been associated and genetic testing is often low yield 15-17."
"Zika virus"
"Fukuyama muscular dystrophy"
"Some cases are genetic (e.g. as one of many heterogeneous manifestations of 22q11.2 deletion syndromes) and others form a distinct phenotype (e.g. bilateral frontoparietal polymicrogyria, mapped to a genetic mutation and GPR56 mutation 16q2.2-21) 8,9."
Expected headings
"Associations"
"Signal intensity"
"Morphology"
"Polymicrogyria may represent both a malformation and disrupted development 14. It is thought to result from an insult in utero occurring toward the end of neuronal migration and early phase of cortical organisation (between 17 and 26 weeks gestation) 1,10,13. There is an abnormal arrangement and excessive folding of cerebral cortical cell layers which can be associated with fusion of the gyral surfaces 3."
"CT can only resolve thickened poorly formed gyri, the microgyri are too small to identify. Associated abnormalities may be seen however (e.g. schizencephaly)."