"Histopathology demonstrates a granulomatous response to injected particles in and around pulmonary arterioles and capillaries (angiogranulomatous response). The disease is usually chronic and progressive, although milder and spontaneously resolving forms can be seen mainly with starch as it is rapidly cleared from the lungs 1. The severity of the disease is usually related to the amount and timing of the drug injection(s)."
"widespread small (2-3 mm) well-defined nodules; there may be mid-to-lower zone predilection."
"Although it was originally described as being caused by talc particles in patients injecting crushed methadone tablets intravenously, clinically and radiologically indistinct patterns have been observed in response to other excipients such as microcrystalline cellulose, crospovidone, and starch."
"widespread small (2-3 mm) well-defined nodules; there may be mid-to-lower zone predilection."