"The condition was described by French physicians Raymond Garcin (1897-1971), George Charles Guillain (1876-1961) and Théophile A J Alajouanine (1890-1980) in their 1926 case series 7."
"Garcin syndrome is classically defined as being caused by a malignant process causing an osteoclastic lesion of the skull base 1-6, which can cause cranial neuropathies through cranial nerve impingement at their skull base foraminal exits or during their extracranial paths 2. In this context, a wide variety of primary malignancies have been implicated, e.g. nasopharyngeal carcinoma, haematological malignancies, or metastases 1-6. However, the syndrome has also been more broadly attributed to a range of non-malignant pathologies which may or may not involve the bony skull base, e.g. giant cell tumour of bone, rhinocerebral mucormycosis, giant internal carotid artery aneurysm, or basal leptomeningitis and hypertrophic pachymeningitis 1-6."
"Garcin syndrome is classically defined as being caused by a malignant process causing an osteoclastic lesion of the skull base 1-6, which can cause cranial neuropathies through cranial nerve impingement at their skull base foraminal exits or during their extracranial paths 2. In this context, a wide variety of primary malignancies have been implicated, e.g. nasopharyngeal carcinoma, haematological malignancies, or metastases 1-6. However, the syndrome has also been more broadly attributed to a range of non-malignant pathologies which may or may not involve the bony skull base, e.g. giant cell tumour of bone, rhinocerebral mucormycosis, giant internal carotid artery aneurysm, or basal leptomeningitis and hypertrophic pachymeningitis 1-6."
"Garcin syndrome, also known as hemibasal syndrome or Guillain-Alajouanine-Garcin syndrome, is characterised by progressive ipsilateral cranial neuropathies of at least seven cranial nerves, with no evidence of raised intracranial pressure, long-tract signs, or cerebellar signs, classically attributable to a malignant osteoclastic skull base lesion."
"other symptoms specifically attributable to the underlying aetiology (e.g. cervical lymphadenopathy)"