"Gliosarcomas can be very similar to glioblastomas in appearance. They are usually broad-based peripherally located lesions with possible direct dural invasion or only reactive dural thickening (dural tail) 3-7."
"T1: heterogeneous and hypointense mass"
"T1C+ (Gd): thick irregular and rim-like or ring enhancement"
"The vast majority of gliosarcomas arise from WHO grade 4 astrocytomas (i.e. glioblastoma), however, rarely they can also arise from ependymomas or oligodendrogliomas in which case they can be referred to as ependymosarcomas and oligosarcomas respectively 8."
"The vast majority of gliosarcomas arise from WHO grade 4 astrocytomas (i.e. glioblastoma), however, rarely they can also arise from ependymomas or oligodendrogliomas in which case they can be referred to as ependymosarcomas and oligosarcomas respectively 8."
"The immunohistochemical features reflect the biphasic microscopy with an astrocytic component (GFAP positive) and the sarcomatous component being evident."
"Almost all gliosarcomas are IDH wild-type. They are, however, PTEN and TP53 mutated and demonstrate CDKN2A deletion. EGFR amplification is usually not present 9."
"Almost all gliosarcomas are IDH wild-type. They are, however, PTEN and TP53 mutated and demonstrate CDKN2A deletion. EGFR amplification is usually not present 9."
"These tumours vary in appearance depending on the relative amounts of sarcomatous tissue and astrocytic tissue. When the former is dominant, then these lesions appear similar to metastases; well-circumscribed and firm. When the astrocytic component is abundant, then appearances are identical to a glioblastoma 8."
"Almost all gliosarcomas are IDH wild-type. They are, however, PTEN and TP53 mutated and demonstrate CDKN2A deletion. EGFR amplification is usually not present 9."