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hereditary-angiopathy-with-nephropathy-aneurysms-and-muscle-cramps-syndrome

Acronyms

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"Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) syndrome is an autosomal dominant monogenic COL4A1-related disorder."

Line 1:82 · 'HANAC' has no definition. Spell it out if it's unfamiliar to the audience.

"The cardinal features of HANAC syndrome are helpfully described in the name of the condition:"

Line 5:29 · 'HANAC' has no definition. Spell it out if it's unfamiliar to the audience.

"In addition to the HANAC features, and similar to COL4A1 brain small-vessel disease, additional body systems may also be involved, including the eyes (bilateral retinal artery tortuosity, cataracts, retinal haemorrhages), extracranial vasculature (Raynaud phenomenon), and heart (arrhythmias) ^1-3."

Line 12:23 · 'HANAC' has no definition. Spell it out if it's unfamiliar to the audience.

"HANAC syndrome is an autosomal dominant condition resulting from a mutation to the COL4A1 gene, located on the long arm of chromosome 13, that normally encodes for the alpha-1 chain of type IV collagen ^1-3. Type IV collagen is an important component of basement membranes in many tissues, as demonstrated by the wide variety of body systems involved in this condition ^1-3."

Line 14:4 · 'HANAC' has no definition. Spell it out if it's unfamiliar to the audience.

"MRI is the investigation of choice and demonstrates widespread confluent, bilateral, symmetric white matter hyperintensities on T2-weighted sequences, with relative sparing of subcortical U-fibres ^1,2. There may be additional features less commonly seen, including dilated perivascular spaces and cerebral microhaemorrhages ². Evidence of intracerebral macrohaemorrhage, ischaemic stroke, or porencephaly is generally not seen in HANAC syndrome ^1,2."

Line 20:498 · 'HANAC' has no definition. Spell it out if it's unfamiliar to the audience.

Emphasis

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"Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) syndrome is an autosomal dominant monogenic COL4A1-related disorder."

Line 1:145 · Italics should be used only in exceptional circumstances: '<em>COL4A1</em>'

Line 12:57 · Italics should be used only in exceptional circumstances: '<em>COL4A1</em>'

Headings Valid

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Expected headings

H1 Terminology
H1 Usage
H1 Epidemiology
H2 Risk factors
H2 Associations
H1 Clinical presentation
H2 Complications
H1 Diagnosis
H2 Diagnostic criteria
H2 Diagnostic clues
H1 Pathology
H2 Aetiology
H2 Location
H2 Classification
H2 Macroscopic appearance
H2 Microscopic appearance
H2 Immunophenotype
H2 Markers
H2 Genetics
H1 Radiographic features
H2 Plain radiograph
H2 Mammography
H2 Antenatal ultrasound
H2 Transoesophageal echocardiography
H2 Ultrasound
H2 CT
H3 Dual-energy CT
H2 Angiography (DSA)
H2 MRI
H2 CT/MRI
H2 Nuclear medicine
H3 PET-CT
H3 PET-MRI
H1 Radiology report
H1 Treatment and prognosis
H2 Complications
H1 History and etymology
H1 Differential diagnosis
H2 Clinical differential diagnosis
H1 Practical points
H1 See also

"CTA / MRA"

Line 21:1 · "CTA / MRA" is not a recognised heading for this article type.

Commas

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Line 12:37 · More than 5 commas in a single sentence might make it more difficult to read.

Links

col4a1-related-disorders

col4a1-brain-small-vessel-disease

cataract

raynaud-phenomenon

subcortical-u-fibres-3

perivascular-spaces

cerebral-microhaemorrhage

intracerebral-hemorrhage-1

ischemic-stroke-2

porencephaly

saccular-cerebral-aneurysm

internal-carotid-artery-1

Lint: hereditary-angiopathy-with-nephropathy-aneurysms-and-muscle-cramps-syndrome