"Immunodeficiency-associated CNS lymphomas are recognised in the WHO classification of CNS tumours (2021, 5th edition) as a single diagnosis nested within primary CNS lymphomas 1. Within this diagnosis are a number of entities previously recognised as separate entities, all of which share immunocompromised hosts, large B-cell morphology and are EBV-related."
"EBV-positive diffuse large B-cell lymphoma of the elderly"
"HTLV"
"Immunodeficiency-associated CNS lymphomas are of B-cell origin and therefore have the usual B-cell markers (CD19, CD20 and CD79a). In most instances, and unlike sporadic primary CNS lymphomas, these tumours are associated with prior EBV infection 1."
"IgA deficiency"
"Immunodeficiency-associated CNS lymphomas are of B-cell origin and therefore have the usual B-cell markers (CD19, CD20 and CD79a). In most instances, and unlike sporadic primary CNS lymphomas, these tumours are associated with prior EBV infection 1."
"They express EBER1, EBER2, LMP1 and EBNA1-6 1."