Expected headings
"Associations"
"increased incidence of autoimmune manifestations and malignancies (e.g. primary CNS lymphoma)"
"The pathophysiology relates to structural mutation with defective actin polymerisation in haematopoietic cells as a result of deficient or dysregulated activity of the Wiskott-Aldrich syndrome protein (WASp) which has multiple functions. There is a poor antibody response to polysaccharide antigens. Low IgM, but high IgA and IgE levels."
"History and etymology"
"It was originally described by Wiskott in 1937 as a triad of ear discharge, eczema and thrombocytopenia. The genetics, i.e. X-linked recessive disorder, were described by Aldrich 7 in 1954."