"Although frontal and temporal hypoperfusion can be similar to that seen in Alzheimer disease, occipital hypoperfusion and the cingulate island sign (preserved metabolism of the posterior cingulate) on FDG-PET 1 may aid in differentiation from other types of dementia, especially Alzheimer disease 8,9,13,14. If the occipital lobe is not involved, dementia with Lewy bodies and Alzheimer disease cannot be distinguished on the basis of their PET signatures."
"Prodromal symptoms, such as gastrointestinal symptoms (constipation, gastroparesis, nausea), REM sleep behaviour disorder, anosmia, and anxiety, can also occur 14,18."
"Dementia with Lewy bodies vs Parkinson disease dementia"
"Dementia with Lewy bodies vs Alzheimer disease"
Expected headings
"Dementia with Lewy bodies vs Parkinson disease dementia"
"Dementia with Lewy bodies vs Alzheimer disease"
"FDG-PET"
"Amyloid PET"
"I-123 ioflupane SPECT"
"Prodromal symptoms, such as gastrointestinal symptoms (constipation, gastroparesis, nausea), REM sleep behaviour disorder, anosmia, and anxiety, can also occur 14,18."
"Unlike Parkinson disease, patients with dementia with Lewy bodies respond less readily to levodopa combination therapies and also more sensitive to neuroleptic drugs, which may cause rigidity, reduced consciousness, pyrexia, falling, postural hypotension and collapse 3. However, dementia with Lewy bodies responds favourably to acetylcholinesterase inhibitors (e.g. rivastigmine, donepezil), even more-so than Alzheimer disease 6."
"There are three entities to be distinguished in this gamut 18:"
"In dementia with Lewy bodies, dementia precedes or accompanies parkinsonism (or at least becomes clinically evident within an arbitrary 12 months of presentation 5,18). Patients with Parkinson disease, on the other hand, will not infrequently also develop dementia. However, it typically occurs years after the onset of parkinsonian motor symptoms 1,2,5. Such cases are then referred to as Parkinson disease dementia (PDD); at least an arbitrary 12 months of parkinsonism without dementia need to precede cognitive impairment 5,7."
"imaging: prominent involvement of hippocampi on structural imaging; a positive amyloid PET does not exclude dementia with Lewy bodies 20,21"
"imaging: more pronounced frontal/temporal atrophy; left-to-right asymmetry"
"History and etymology"