"When reported, these lesions have a striking predilection for the intertrochanteric region of the femur (80-95%) 1,6-8,11-12."
"Cellular areas with spindle or stellated cells show immunoreactivity consistent with a bone-forming tumour (positive for smooth muscle actin and SATB2) 11.A GNAS p.Arg844Cys mutation has been identified, supporting the hypothesis that these tumours are part of the fibrous dysplasia spectrum, which also harbours GNAS mutations 10,11."
"Plain radiograph/CT "
"if the lesion is aggressive/malignant (e.g. osteosarcoma) then management will be dictated by the histology and stage."
"This tumour has not found a permanent place in the WHO classification of soft tissue and bone tumours since its description in 1986. Currently (5th edition, 2020) the term "liposclerosing myxofibrous tumour" does not have its own entry and merely appears as "no longer recommended" terminology within the diagnosis of fibrous dysplasia 10."
"Cellular areas with spindle or stellated cells show immunoreactivity consistent with a bone-forming tumour (positive for smooth muscle actin and SATB2) 11.A GNAS p.Arg844Cys mutation has been identified, supporting the hypothesis that these tumours are part of the fibrous dysplasia spectrum, which also harbours GNAS mutations 10,11."
"Cellular areas with spindle or stellated cells show immunoreactivity consistent with a bone-forming tumour (positive for smooth muscle actin and SATB2) 11.A GNAS p.Arg844Cys mutation has been identified, supporting the hypothesis that these tumours are part of the fibrous dysplasia spectrum, which also harbours GNAS mutations 10,11."
Expected headings
"Plain radiograph/CT "
"This tumour has not found a permanent place in the WHO classification of soft tissue and bone tumours since its description in 1986. Currently (5th edition, 2020) the term "liposclerosing myxofibrous tumour" does not have its own entry and merely appears as "no longer recommended" terminology within the diagnosis of fibrous dysplasia 10."
"The tumour comprises a wide mixture of tissues of histological elements, including lipomatous, fibroxanthomatous, myxomatous, and myxofibromatous components 5 and is not a universally accepted pathological entity, most likely falling within a spectrum of manifestations of fibrous dysplasia, and is classified as such in the current (5th edition, 2020) WHO classification of soft tissue and bone tumours 3,10,11."
"History and etymology"