"Polyostotic form "
"T1: usually intermediate to low heterogeneous signal 5"
"T2: variable signal 10"
"T1 C+ (Gd): heterogeneous moderate to avid contrast enhancement 9,10"
"Demonstrates increased tracer uptake on Tc99 bone scans (lesions remain metabolically active into adulthood)."
"Fibrous dysplasia accounts for the "F" in the popular mnemonic for lucent bone lesions FEGNOMASHIC."
"evidence of GNAS activating missense mutations"
"With sensitive methods, GNAS activating missense mutations, which normally encode the alpha subunit of the stimulatory G-protein, can be detected in the majority of cases (~64-83%) 18, particularly those involving pArg201His and pArg201Cys 1,4. However, the detection rate depends heavily on the sensitivity of the molecular technique used and the proportion of mutant cells in the sample."
"aneurysmal bone cyst: Fibrous dysplasia and ABC can coexist in the same bone, and some literature shows fibrous dysplasia developing into ABC"
"aneurysmal bone cyst: Fibrous dysplasia and ABC can coexist in the same bone, and some literature shows fibrous dysplasia developing into ABC"
"If features are typical, the lesion can be categorised as Bone-RADS 1 on CT or MRI 6."
"evidence of GNAS activating missense mutations"
"aneurysmal bone cyst: Fibrous dysplasia and ABC can coexist in the same bone, and some literature shows fibrous dysplasia developing into ABC"
"Looser zones"
Expected headings
"Monostotic form"
"Polyostotic form"
"Monostotic form"
"Polyostotic form "
"Associations"
"Pelvis and ribs"
"Extremities"
"Complications"
"Fibrous dysplasia is uncommon, occurs in children and adults and can affect all age groups 1,2. It is usually first diagnosed in children and young adults. The true incidence is not known, but it is estimated to account for ~5% of benign bone lesions 3,4. There is no gender predilection 1."
"Mazabraud syndrome: soft-tissue myxomas (rare); typically multiple intramuscular lesions in the vicinity of most severely affected bone"
"Fibrous dysplasia was first described by the American bone pathologist Louis Lichtenstein in 1938, and the clinical, radiological and histological spectrum of findings was later characterised by him and his colleague Henry Louis Jaffe in 1942 13,14."